Protein Details: Short transient receptor potential channel 3

Protein ID

ICDB_Pro_0822

Protein Name

Short transient receptor potential channel 3

Gene Name

TRPC3; TRP3

Organism

Homo sapiens (Human)

Length

921 amino acids

AlphaFoldDB

AF-Q13507-F1-model_v4.pdb

Function

Sequence

MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE

PDB Structures

5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

158;525;528;543;871;874;876;883

Disease

Spinocerebellar Ataxia 41 and Alternating Hemiplegia Of Childhood 2

Location

Expressed predominantly in brain and at much lower levels in ovary; colon; small intestine; lung; prostate; placenta and testis

DOI ID

10.1016/s0092-8674(00)81233-7; 10.1016/s0092-8674(00)80302-5; 10.1073/pnas.0409908102; 10.1038/nature03466; 10.1101/gr.2596504; 10.1073/pnas.92.21.9652; 10.1074/jbc.273.15.8675; 10.1074/jbc.273.1.133; 10.1038/24890; 10.1038/16711; 10.1073/pnas.96.26.14955; 10.1074/jbc.m500391200; 10.1016/j.ceca.2007.07.009; 10.1042/bj20091225; 10.1016/j.jmb.2006.12.043; 10.1038/s41422-018-0038-2; 10.1074/jbc.ra118.005066; 10.7554/elife.36852; 10.1016/j.neuron.2021.12.023; 10.1002/mds.26096

RefSeq

NP_001124170.1 [Q13507-2]; NP_003296.1 [Q13507-3]